Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Rafik M. Ghobrial
6550 Fannin St., Houston, TX 77030
Tanzania
Research Article
Allochimeric MHC I-Conditioned T Cells Attenuate Chronic Rejection in Rat Cardiac Model System
Author(s): Thomas Skelton, Andrea M Cordero, Nicole J Nelles, Malathesha Ganachari, Jitinderpal Sidhu, Neelam Tejpal, Yongquan Gong, Junping You, Malgorzata Kloc and Rafik M. GhobrialThomas Skelton, Andrea M Cordero, Nicole J Nelles, Malathesha Ganachari, Jitinderpal Sidhu, Neelam Tejpal, Yongquan Gong, Junping You, Malgorzata Kloc and Rafik M. Ghobrial
Background: We have shown previously that the mutated class I MHC molecules abrogate acute and chronic rejection and attenuate transplant vascular sclerosis (TVS) through the early changes (1-7 days post-transplantation) in T cell and dendritic cell molecular response. Here we studied a cohort of long-term (100 days) graft survival recipients for changes in T cell molecular response, and the role of regulatory T cells in the abrogation of chronic rejection in adoptive transfer experiments.
Methods: Heterotopic cardiac transplants were performed between donor Wistar Furth (WF) and ACI recipient rats. Controls received no treatment or 6 days therapeutic dose of cyclosporine (CsA 10mg/kg). The experimental group of primary ACI recipient received, peri-operatively, the allochimeric [[α]1h l/u]-RT1.Aa MHC I mol.. View More»
DOI:
10.4172/2155-9899.1000108