Journal of Thyroid Disorders & Therapy
Open Access
ISSN: 2167-7948
ISSN: 2167-7948
Radoslaw Muszkieta
Poland
Research Article
Experimental Investigation of Acute and Delayed Renal Effect of Exogenous Thyroxine
Author(s): Sergiy Dolomatov, Radoslaw Muszkieta and Walery Zukow
Sergiy Dolomatov, Radoslaw Muszkieta and Walery Zukow
Introduction: Normally, thyroid hormones are important regulators of metabolic processes in mammals.
Aim: To study the renal function of rats in a single dose of thyroxine, as well as analysis of remote renal effects of experimental hyperthyroidism.
Materials and methods: The study used inbred male rats massing 200-250 g, the experimental hyperthyroidism caused a 10-day daily intragastric sodium salt of thyroxine, suspended in 1% of starch gel. Thyroxine produced by Berlin Chemie (Germany) was administered to 20 micrograms per 100 g of body mass. The function of the kidneys of rats were studied under conditions of induced diuresis induced by water stress, 24 h after the single purpose of thyroxine, 24 h after the completion of the 10-day administration of the hormone, as well as 14 days after completion of the 10-d.. View More»
DOI:
10.4172/2167-7948.1000105