Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Prathiba Chichurakanahalli Srinivasan

Prathiba Chichurakanahalli Srinivasan
SV Dental College,
Bangalore, Karnataka

  • Review Article
    Neutrophils-the Sentinels of Periodontal Innate Immunity
    Author(s): Prathiba Chichurakanahalli SrinivasanPrathiba Chichurakanahalli Srinivasan

    The neutrophils play a pivotal role in the innate immune response to periodontal microorganisms. They are rapidly recruited to the dentogingival area where there is accumulation of dental plaque. The antimicrobial armamentarium that they possess not only eliminates the microbes but also partly contributes to the tissue destruction seen in periodontitis. Hence, their action is akin to that of a double-edged sword. Defects in neutrophil numbers or genetic abnormalities in neutrophil migration, chemotaxis and phagocytosis manifest as severe forms of aggressive periodontitis, emphasizing the importance of these cells in innate immunity. Over the past few decades, extensive research in the field of neutrophil cell biology has revealed fascinating facts about this cell. The discovery of neutrophil extracellular traps (NETs) is a novel concept and is considered as the central aspect of innat.. View More»
    DOI: 10.4172/2155-9899.S13-002

    Abstract PDF

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