Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Ping Mu
Memorial Sloan Kettering Cancer Center, Human Oncology and Pathogenesis Program,
1275 York Avenue, New York, NY, 10065
Tanzania
Review Article
MicroRNAs in Prostate Cancer: Small RNAs with Big Roles
Author(s): Ping Mu, Su Deng and Xiaozhou FanPing Mu, Su Deng and Xiaozhou Fan
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression either by mediating translational repression or reducing the stability of a target mRNA. Deregulated expression of miRNAs is a common feature of human cancers and a growing body of evidence demonstrates the role of miRNAs as either oncogenes or tumor suppressors. Many miRNAs have been reported to be associated with the pathogenesis of primary prostate cancer (PCa) and the development of castration resistant prostate cancer (CRPC). PCa is the most common cancer and second leading cause of cancer death in American men. Although patients with primary PCa can be treated with chemotherapy and hormone therapy, many of them will develop resistance to conventional therapies and progress to a more sever condition called CRPC, which remains one of the most difficult cancers to treat. Since em.. View More»
DOI:
10.4172/2155-9899.1000315