Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Phileno Pinge-Filho

Phileno Pinge-Filho
Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina,
86051-970, Londrina, Paraná

  • Review Article
    Macrophage Polarization in Chagas Disease
    Author(s): Nagela Ghabdan Zanluqui, Pryscilla Fanini Wowk and Phileno Pinge-FilhoNagela Ghabdan Zanluqui, Pryscilla Fanini Wowk and Phileno Pinge-Filho

    Macrophages are terminally differentiated cells of the mononuclear phagocytic system, which play an indispensable role in the maintenance of homeostasis and defense. Macrophages can be phenotypically polarized by the microenvironment to mount specific functional responses. Polarized macrophages can be broadly classified into two main groups: classically activated macrophages (M1), whose prototypical activating stimuli are IFN-γ and LPS, and alternatively activated macrophages (M2), further subdivided in M2a (after exposure to IL-4 or IL-13), M2b (immune complexes in combination with IL-1β or LPS) and M2c (IL-10, TGF-β or glucocorticoids). M1 exhibit potent microbicidal properties and promote strong IL-12-mediated Th1 responses, while M2 macrophages support Th2- associated effector functions. Here we review the main functions of polarized mac.. View More»
    DOI: 10.4172/2155-9899.1000317

    Abstract PDF

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