Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Perdigón G
Centro de Referencia para Lactobacilos (CERELA-CONICET),
Chacabuco 145 (T4000ILC), Tucumán
Argentina
Research Article
Stimulation of Innate Immune Cells Induced by Probiotics: Participation of Toll-Like Receptors
Author(s): Maldonado GC, Lemme-Dumit JM, Thieblemont N, Carmuega E, Weill R and Perdigón GMaldonado GC, Lemme-Dumit JM, Thieblemont N, Carmuega E, Weill R and Perdigón G
Objective: The present work aimed to study the functionality of macrophages from different locations (peritoneum, spleen and Peyer´s patches) when they were stimulated with probiotics microorganisms: Lactobacillus casei CRL 431 and Lactobacillus paracasei CNCM I-1518 or a Probiotic Fermented Milk (PFM) through Toll-Like Receptors (TLRs), prior challenged with agonists or antagonists of TLRs. Methods: BALB/c mice received in the drinking water, the probiotic bacteria (L. casei CRL 431 and L. paracasei CNCM I-1518) or the PFM. We focused our investigation mainly on the phagocytic activity of macrophages from peritoneum, spleen and Peyer’s patches and cytokine production were evaluated prior challenged with TLR2 and TLR4 agonists or antagonists. The microbicidal activity of macrophages and against an i.. View More»
DOI:
10.4172/2155-9899.1000283