Journal of Thyroid Disorders & Therapy
Open Access
ISSN: 2167-7948
+44 1300 500008
ISSN: 2167-7948
+44 1300 500008
Pavani Srimatkandada
Boston University School of Medicine,
Boston MA, 88 East Newton Street, Room H3600, Boston, MA 02118
Tanzania
Case Report
Severe Autoimmune Hyperthyroidism in Two Patients with Pulmonary Arterial Hypertension after Treatment with Epoprostenol
Author(s): Pavani Srimatkandada and Andrea D. CovielloPavani Srimatkandada and Andrea D. Coviello
Objective: To highlight the increased risk of severe hyperthyroidism leading to decompensation of pulmonary and cardiac hemodynamics post initiation of epoprostenol for treatment of pulmonary arterial hypertension (PAH).
Methods: Review of literature shows an increased incidence of autoimmune thyroid disease in patients
undergoing treatment of PAH with epoprostenol. We describe two incidences of seropositive thyrotoxicosis associated with acute decompensation of pulmonary and cardiac function.
Results: We report two patients with no prior history of thyroid disease who developed severe hyperthyroidism after initiation of epoprostenol.
Conclusions: Clinicians should be aware of the potential for development of severe hyperthyroidism leading to rapid decompensation in cardiac and respiratory .. View More»
DOI:
10.4172/2167-7948.1000176