Immunome Research

Immunome Research
Open Access

ISSN: 1745-7580


Paul A Gatenby

Paul A Gatenby
Medical School, School of Clinical Medicine, Australian National University,
Bldg 4 level 2, The Canberra Hospital, PO Box 11, Woden, ACT, 2606

  • Review Article
    The Role of Environmental Factors in the Pathogenesis of Anti-Neutrophil Antibody Associated Vasculitis

    Author(s): Paul A GatenbyPaul A Gatenby

    This review seeks to critically examine the environmental factors reported to be associated with anti-neutrophil antibody associated systemic vasculitis. The published literature was searched in a systematic fashion. From this emerges strong evidence for a latitude gradient in the case of granulomatous polyangiitis and eosinophilic granulomatous polyangiitis; both appear more common at high latitudes. Microscopic polyangiitis does not demonstrate this. Latitude affects ultraviolet radiation exposure and the relationship of increased incidence of granulomatous polyangiitis and eosinophilic polyangiitis with decreased ultraviolet radiation exposure is much stronger. The most plausible explanation is vitamin D levels, a hormone known to be vital for normal immune function and largely synthesised in humans secondary to ultraviolet radiation exposure. Case control studies demonstrate a con.. View More»
    DOI: 10.4172/1745-7580.1000073


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