Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Ogola PE
Kenya
Research Article
Immunological Profiles in HIV Positive Patients with or without Opportunistic Infections and the Influence of Highly Active Antiretroviral Therapy: A Systematic Review and Update
Author(s): Wambani JR, Kiboi NG, Makori WM, Ogola PE and Rachuonyo HOWambani JR, Kiboi NG, Makori WM, Ogola PE and Rachuonyo HO
Background: Immune abnormalities are occasioned during HIV infection consequently predisposing opportunistic infections. In part, these derangements result from impaired expression of a number of immunologically important cytokines. However, exact mechanisms behind HIV infectivity on immune system maturation and cytokine production is not well elucidated, more specifically during treatment with HAART. As such, this review compiles data from various studies with the aim of understanding alterations in cytokine network during the course of HIV infection, while assessing the impact of antiretroviral treatment towards cytokine expression.
Methods: Studies describing cytokine profiles among HIV infected cohorts with or without opportunistic infections (from January, 1990-March, 2016) were carefully inspected from various databases including; PubMed,.. View More»
DOI:
10.4172/2155-9899.1000429