Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Nicola C. G. Stein
Germany
Case Report
Antibodies to Ribosomal P in Lupus Psychosis Resolving after Rituximab plus Cyclophosphamide – A Case Report
Author(s): Nicola C. G. Stein, Karsten Conrad and Martin AringerNicola C. G. Stein, Karsten Conrad and Martin Aringer
Background: Central nervous disease manifestations in systemic lupus erythematosus (SLE) are variable, but may be severe. A subset of these manifestations in the central nervous system (CNS) is caused by antibodies. One antibody in particular, against ribosomal P, is supposed to play a significant role in neuropsychiatric SLE, especially lupus psychosis. Our case supports this idea.
Case: We present a case of a young female who developed severe lupus psychosis after discontinuation of her immunosuppressive treatment for systemic lupus erythematosus without prior central nervous or psychiatric manifestations. Cerebral imaging and liquor analysis was unremarkable, serum analysis showed high titers of both, anti-dsDNA and anti-ribosomal P antibodies. When disease could not be controlled with high dose methylprednisolone, a combination of cyclophos.. View More»
DOI:
10.4172/2155-9899.1000168