Journal of Tumor Research
Open Access
ISSN: 2684-1258
ISSN: 2684-1258
Nan-Shan Chang
Institute of Molecular Medicine,
Tainan, Taiwan
Editorial
WWOX Drives T Leukemia Cell Maturation via IκBα/WWOX/ERK Signal Pathway
Author(s): Nan-Shan ChangNan-Shan Chang
Forced differentiation therapy has been shown to be effective in suppressing promyelocytic leukemia cell growth and other types of cancer cells in patients. A combination of calcium ionophore and phorbol ester is effective in inducing terminal maturation of T-cell acute lymphoblastic leukemia (T-ALL), in which it requires the signaling of IκBα/WWOX/ERK. While WWOX is generally regarded as a tumor suppressor, this editorial view addresses the critical role of WWOX phosphorylation at Ser14 and de-phosphorylation at Tyr33 that drives T-ALL maturation... View More»
DOI:
10.35248/2684-1258.17.3.e101