Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Min Fang

Min Fang
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences,
NO.1 Beichen West Road, Chaoyang District, Beijing 100101

  • Review Article
    Natural Killer cells in Innate Defense against Infective Pathogens
    Author(s): Dongfang Wang, Yongchao Ma, Jing Wang, Xiaoman Liu and Min FangDongfang Wang, Yongchao Ma, Jing Wang, Xiaoman Liu and Min Fang

    Infectious diseases cause over 300 million illnesses and more than 5 million deaths each year worldwide. Understanding how components of the host immune system function to control disease-causing pathogens is critically important to develop strategies for preventing and controlling these diseases. With the discovery of innate immune receptors, we are beginning to appreciate the important role of innate immunity in the defense against infectious diseases. NK cells are a critical cell population in innate immunity, providing first line of defense against a variety of pathogens. NK cells mediate protection by direct killing of infected target cells and producing cytokines (mainly IFN-γ and TNF) that shape innate and adaptive immune responses. Recent studies have focused on the mechanisms by which NK cells recognize and respond to viruses, bacteria and parasites, and also the role of.. View More»
    DOI: 10.4172/2155-9899.S13-006

    Abstract PDF

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