Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Michael C. Levin
Link Building Room 415, 855 Monroe Avenue, Memphis, TN 38163
Tanzania
Review Article
Autoantibodies to Non-myelin Antigens as Contributors to the Pathogenesis of Multiple Sclerosis
Author(s): Michael C. Levin, Sangmin Lee, Lidia A. Gardner, Yoojin Shin, Joshua N. Douglas and Chelsea CooperMichael C. Levin, Sangmin Lee, Lidia A. Gardner, Yoojin Shin, Joshua N. Douglas and Chelsea Cooper
For years, investigators have sought to prove that myelin antigens are the primary targets of autoimmunity in multiple sclerosis (MS). Recent experiments have begun to challenge this assumption, particularly when studying the neurodegenerative phase of MS. T-lymphocyte responses to myelin antigens have been extensively studied, and are likely early contributors to the pathogenesis of MS. Antibodies to myelin antigens have a much more inconstant association with the pathogenesis of MS. Recent studies indicate that antibodies to non-myelin antigens such as neurofilaments, neurofascin, RNA binding proteins and potassium channels may contribute to the pathogenesis of MS. The purpose of this review is to analyze recent studies that examine the role that autoantibodies to non-myelin antigens might play in the pathogenesis of MS.
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DOI:
10.4172/2155-9899.1000148