Journal of Thyroid Disorders & Therapy
Open Access
ISSN: 2167-7948
+44 1300 500008
ISSN: 2167-7948
+44 1300 500008
Mehtap Evran
Division of Endocrinology,
01330 Adana
Turkey
Case Report
Metabolic and Cardiovascular Aspects of Subclinical Hypothyroidism: Effects of L-Thyroxin Replacement Therapy
Author(s): Mehtap Evran, Murat Sert, Tamer Tetiker and Murat ÇaylıMehtap Evran, Murat Sert, Tamer Tetiker and Murat Çaylı
Background: Subclinical hypothyroidism (SH) is a common clinical issue, presented with high serum TSH and normal T4, T3 levels. Various clinical and metabolic derangements were reported related to SH. L-T4-replacement is a challenge in daily practice. We investigated the efficacy of L-T4-replacement on certain metabolic and cardiovascular parameters in subjects with SH.
Methods: Fifty-three (40 female; 13 male) subjects were included. Of the 53 subjects, 29 were randomly given L-T4 replacement, 24 were followed as control group through 6-months. Before L-T4 replacement (basal) and at the end of the study; symptoms, physical examination, serum metabolic parameters, Holter ECG and trans-thoracic echocardiography were performed. Two groups were compared.
Results: Mean age of the patients was 44.02 ± 13.9; body .. View More»
DOI:
10.4172/2167-7948.1000112