Journal of Clinical and Cellular Immunology
Open Access

Masashi Akiyama

Publications

• Research Article
  High-avidity IgG Autoantibodies against DFS70/LEDGF in Atopic Dermatitis
  Author(s): Kanako Watanabe, Yoshinao Muro, Kazumitsu Sugiura and Masashi AkiyamaKanako Watanabe, Yoshinao Muro, Kazumitsu Sugiura and Masashi Akiyama
  
  Objective: Dense fine speckles 70 kDa protein (DFS70)/lens epithelium-derived growth factor (LEDGF) autoantibodies have been reported to be present in serum samples from patients with atopic dermatitis (AD) as well as from healthy individuals (HI). We previously revealed that IgE- and IgG4-anti-DFS70 autoantibodies were found in patients with AD and that their presence was associated with high levels of thymus-and activation-regulated chemokine. Our aim was to determine the avidity of IgG-anti-DFS70 antibodies in patients with AD relative to that avidity in HI.Patients and methods: This study was undertaken to measure the avidity of IgG-anti-DFS70 autoantibodies in AD and HI groups, in comparison with the major recall antigen diphtheria toxoid (DT) and to evaluate the relevance of IgG-anti-DFS70 autoantibodies to the disease. We measured the avi.. View More»
  DOI: 10.4172/2155-9899.1000170

  Abstract PDF

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