Does Pioglitazone Increase the Risk of Bladder Cancer in Japanese Diabetic Patients?
Author(s): Kanya Kaga, Kazuhiro Araki, Manato Kanesaka, Masahiro Sugiura, Kyokushin Ho, Hiroshi Masuda, Satoko Kojima and Yukio NayaKanya Kaga, Kazuhiro Araki, Manato Kanesaka, Masahiro Sugiura, Kyokushin Ho, Hiroshi Masuda, Satoko Kojima and Yukio Naya
Abstract Objective: To investigate the risk of bladder cancer with pioglitazone, the data of diabetic patients treated at Teikyo Chiba Medical Center were analyzed retrospectively. Methods: From February 2009 to October 2011, 720 patients were treated with pioglitazone, and 742 patients were not treated with pioglitazone at Teikyo University Chiba Medical Center. The numbers of newly diagnosed bladder cancers from February 2009 to December 2013 in these patients and the occurrence of bladder cancer among type 2 diabetes mellitus patients were identified. The duration of diabetes, sex, age, smoking, and medication for diabetes were obtained from the medical records. The occurrence of bladder cancer was defined as incident cases after the initiation of pioglitazone. Statistical significance was analyzed by Fisher’s exact test... Read More»