Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Mary C Dinauer
Departments of Pediatrics (Hematology/Oncology), Microbiology/Immunology, and Medical and Molecular Genetics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA
Mary C Dinaueris distinguished Chair in Pediatric Research Professor of Pediatrics and of Pathology and Immunology Scientific Director, Children’s Discovery Institute. Her present research on the leukocyte NADPH oxidase and the role of oxidant production by neutrophils and macrophages in microbial killing, the inflammatory response and regulation of adaptive immunity. Other studies focus on the development of gene replacement therapy for X-linked CGD, utilizing viral vectors to introduce the corrective gene into murine and human hematopoietic stem cells, and novel conditioning strategies for marrow transplantation. These questions are being studied using a combination of molecular and cell biology approaches and animal models, including mice generated by gene targeting
Hematology, Oncology, Developmental Biology, Immunology,Adaptive immunity,Gene replacement therapy,stem cells