Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Marina G Silveira

Marina G Silveira

Louis Stokes Cleveland VA Medical Center and Case Medical Center, 10701 East Blvd 111E (W), Cleveland, OH, 44106

  • Review Article
    Overlap Syndromes of Autoimmune Liver Disease
    Author(s): Marina G SilveiraMarina G Silveira

    Autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are chronic liver diseases of presumed autoimmune origin. Conditions exhibiting features of two different autoimmune liver diseases are commonly designated overlap syndromes, although there is no current agreement on what constitutes an overlap syndrome or specific diagnostic criteria. Identification of patients with features of overlap syndrome is relevant for management as outcomes may differ from outcomes of patients with diagnosis of classic autoimmune liver diseases and treatment may need to be adjusted. Due to their rarity, no large therapeutic trials are available and treatment of overlap conditions is empirical and based upon extrapolation of data from the primary autoimmune liver diseases. AIH-PBC overlap is the most frequently described overlap syndrome and may be associated .. View More»
    DOI: 10.4172/2155-9899.1000161

    Abstract PDF

Relevant Topics