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Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Margaret Seton

Margaret Seton
Harvard Medical School Director, Metabolic Bone Disease Brigham & Women’s Hospital Rheumatology,
75 Francis St, Boston, MA 02115
Tanzania

Publications
  • Case Report
    Hydroxychloroquine Reverses Alopecia in Autoimmune Polyendocrinopathy- Candidiasis-Ectodermal Dystrophy (APECED): A Case Report
    Author(s): Margaret SetonMargaret Seton

    Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare, autosomal recessive disease characterized by the onset of mucocutaneous candidiasis in childhood, followed by hypoparathyroidism, and in a subset of patients, alopecia and other endocrinopathies and autoimmune diseases. There is no known treatment to mitigate the course of the disease.Goal: To describe the outcomes in a woman with APECED who presented later in her life with Sjogren’s disease and alopecia totalis, and was treated with hydroxychloroquine (HCQ). HCQ was in addition to treatment regimens for mucocutaneous candidiasis with esophageal stricture, hypoparathyroidism, insulin-dependent diabetes, hypothyroidism, B12 deficiency, and autoimmune hepatitis.Methods: Office visits, laboratory studies, including genetic cha.. Read More»
    DOI: 10.4172/2155-9899.1000177

    Abstract PDF

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