Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Margaret Seton
Harvard Medical School Director, Metabolic Bone Disease Brigham & Women’s Hospital Rheumatology,
75 Francis St, Boston, MA 02115
Tanzania
Case Report
Hydroxychloroquine Reverses Alopecia in Autoimmune Polyendocrinopathy- Candidiasis-Ectodermal Dystrophy (APECED): A Case Report
Author(s): Margaret SetonMargaret Seton
Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare, autosomal recessive disease characterized by the onset of mucocutaneous candidiasis in childhood, followed by hypoparathyroidism, and in a subset of patients, alopecia and other endocrinopathies and autoimmune diseases. There is no known treatment to mitigate the course of the disease.Goal: To describe the outcomes in a woman with APECED who presented later in her life with Sjogren’s disease and alopecia totalis, and was treated with hydroxychloroquine (HCQ). HCQ was in addition to treatment regimens for mucocutaneous candidiasis with esophageal stricture, hypoparathyroidism, insulin-dependent diabetes, hypothyroidism, B12 deficiency, and autoimmune hepatitis.Methods: Office visits, laboratory studies, including genetic cha.. View More»
DOI:
10.4172/2155-9899.1000177