ISSN: 2375-4508
+44 1478 350008
Mahsa N
West Indies
Research Article
Prenatal Exposure of Kisspeptin Antagonist on the GonadotropinReleasing Hormone (GnRH) Expression in Rat Model of Polycystic Ovary Syndrome
Author(s): Sareh Z, Azita Zadeh V, Mahsa N, Razieh Bidhendi Y, Asghar G, Amir RA and Fahimeh Ramezani TSareh Z, Azita Zadeh V, Mahsa N, Razieh Bidhendi Y, Asghar G, Amir RA and Fahimeh Ramezani T
Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. Increased GnRH/luteinizing hormone (LH) pulse frequency is a characteristic of endocrine abnormalities in PCOS. Kisspeptin antagonists reduce LH pulse frequency and amplitude and are hence supposed to slow GnRH neuron activity that may adjust GnRH/LH levels in PCOS conditions.Objective: To investigate the impact of kisspeptin antagonist P271 administration during prenatal life to reduce GnRH expression in adulthood in prenatally androgenized (PNA) rats as a model of PCOS.Materials and methods: PNA rats (n=9) and controls (n=9) received P271 on day 20 of their prenatal life, and they were examined in adulthood (110-120 days). The ability of P271 to alter GnRH mRNA expression, and plasma levels of gonado.. View More»
DOI:
10.4172/2375-4508.1000206