Andrology-Open Access

Andrology-Open Access
Open Access

ISSN: 2167-0250

Madhu Jain

Madhu Jain
Lal Bahadur Shastri Colony,
G-11, Karaundi, Varanasi

  • Research Article
    Genetic Polymorphism of CYP1A1 (T6235C) Gene as a Risk Factor for Polycystic Ovary Syndrome
    Author(s): Shuchi Jain, Priyanka Pandey, Madhu Jain and Kiran SinghShuchi Jain, Priyanka Pandey, Madhu Jain and Kiran Singh

    Objective: The aim of this study was to test the association of CYP1A1 gene T6235C polymorphism with Polycystic Ovary Syndrome (PCOS). Methods: In a case control study, 100 women with PCOS (Rotterdam criteria) and 100 ages matched healthy controls were enrolled and compared with respect to CYP1A1 T6235C polymorphism. The clinical, biochemical and Sonographic parameters of wild type (TT), heterozygous (TC), and homozygous mutant (CC) genotypes in PCOS women were compared with that in controls. Results: The risk ratio of bearing TC genotype was 1.3327 (p=0.32), and CC genotype was 2.6084 (p=0.14) in women with PCOS on the whole. However in PCOS women with the Sonographic presence of Polycystic Ovaries (PCO), the risk ratio became significant for TC genotype (OR=1.872; p=0.04) but not for CC genotype (OR=4.05; p=0.08). There was also a significant association of TC and CC genotypes with .. Read More»
    DOI: 10.4172/2167-0250.1000129

    Abstract PDF

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