Journal of Clinical and Cellular Immunology
Open Access

Lund KP

Publications

• Commentary
  Case Report: Anti-HLA-DQα Antibodies Have Clinical Impacts in Highly Immunized Kidney Patients
  Author(s): Lund KP, Hauge AW, Sørensen SS and Bruunsgaard HLund KP, Hauge AW, Sørensen SS and Bruunsgaard H
  
  Context and purpose: Organ exchange programmes are important in order to ensure organs to highly immunized kidney patients. In this case report, we describe a highly immunized patient in an acceptable mismatch program who had an unexpected positive Complement-Dependent Cytotoxicity (CDC) crossmatch with a deceased donor exchange. Main findings: Subsequent evaluation revealed donor specific antibodies characterized by serological epitopes, which included the HLA-DQα chain, were masked in the standard IgG Luminex assay unless the serum was diluted; however, the antibodies demonstrated high MFI values when the serum was pretreated with EDTA or analyzed with the C1q assay. These findings led us to evaluate the extent of masked anti-HLA-DQ antibodies that included HLADQα/ DQβ pairs rather than just the HLA-DQβ chains in 16 high.. View More»
  DOI: 10.4172/2155-9899.1000498

  Abstract PDF

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