Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Lorenzo Mortara
As Assistant Professor he joined the Laboratory of General Pathology and Immunology, Department of Biotechnology and Life Sciences (DBSV),University of Insubria.From 2005
Dr. Mortara obtained his Biological Sciences degree at University of Genoa in 1993, were he also obtained the post-graduate title of Specialist in Allergology and Clinical Immunology in 1997. He followed a Doctorate course (Molecular Biology and Biochemistry) in Paris at University of Paris 7 – Denis Diderot, were he obtained a Ph.D. in Immunology in 1999.
Research activities was focussed on basic and translational tumor immunology, and particularly evaluating innovative strategies of tumor vaccination and immunotherapy.Within this line he is studying in the murine model the tumor-specific CD4+ T helper response and the CD8+ T response after different types of immunization or therapy with cytokines such as IL-12 and IL-15-engineered murine tumor cells, naked IL-12 cytokine DNA, or using mouse (m)TNF-a, targeted to tumor vasculature by the anti-ED-B fibronectin domain antibody, L19(scFv), combined with melphalan. In particular this latter treatment induces a therapeutic immune response in mice that comprise a highly efficient priming of CD4 T cells and consequent activation of CD8 CTL effectors, as demonstrated by in vivo cell subset depletion and adoptive cell transfer experiments.