Andrology-Open Access
Open Access
ISSN: 2167-0250
+44 1300 500008
ISSN: 2167-0250
+44 1300 500008
Li-xin Zheng
China
Research Article
Increased Oxidative DNA Damage in Seminal Plasma of Infertile Men with
Varicocele
Author(s): Qi-ling Wang, Li-xin Tang, Shun-mei Deng, Yun-ge Tang and Li-xin ZhengQi-ling Wang, Li-xin Tang, Shun-mei Deng, Yun-ge Tang and Li-xin Zheng
Objective: To investigate the oxidative DNA damage in the seminal plasma and spermatozoa of infertile men with varicocele and to evaluate the potential relationship between oxidative DNA damage and varicocele.
Methods: This case-control study recruited 180 infertile men with varicocele and 199 infertile men without varicocele and 168 fertile male control subjects. Semen parameters, seminal plasma 8-hydroxy-2-deoxyguanosine (8-OHdG) and sperm DNA Fragmentation Index (DFI) were assessed.
Results: Compared to the infertile men without varicocele and control subjects, infertile men with varicocele exhibited lower sperm concentration, lower progressive motility, lower vitality and lower percentage of normal morphology (all P=0.0001). The seminal content of 8-OHdG and sperm DFI were higher in infertile men with varicocel.. View More»
DOI:
10.4172/2167-0250.1000119