Journal of Thyroid Disorders & Therapy
Open Access
ISSN: 2167-7948
+44 1300 500008
ISSN: 2167-7948
+44 1300 500008
Lisa Arnetz
Karolinska Institutet D2:04 Karolinska University Hospital,
17176 Stockholm
Sweden
Research Letter
Effect of Pioglitazone on Thyroid Hormones and IGF-I in Patients with Type 2 Diabetes
Author(s): Lisa Arnetz, Mikael Lantz, Kerstin Brismar, Neda Rajamand Ekberg, Michael Alvarsson and Mozhgan DorkhanLisa Arnetz, Mikael Lantz, Kerstin Brismar, Neda Rajamand Ekberg, Michael Alvarsson and Mozhgan Dorkhan
Background: Thyroid hormones induce insulin resistance. Pioglitazone is a peroxisome proliferator activated receptor gamma (PPARγ) agonist, used as treatment of type 2 diabetes (T2D) to increase insulin sensitivity. PPARs and thyroid hormone receptors (TRs) induce intracellular effects through similar molecular mechanisms, and the former may inhibit activation of the latter. Pioglitazone has been shown to increase eye protrusion, a symptom linked both to disturbed thyroid hormone levels and orbital edema secondary to increased IGF-I.
Aims: We investigated whether attenuation of insulin resistance with pioglitazone affects thyroid hormone status and IGF-I.
Methods: 48 patients with T2D were treated with pioglitazone for 26 weeks. Thyroid hormones and IGF-I were analyzed before and after treatment.
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DOI:
10.4172/2167-7948.1000139