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Mucosal Immune Regulation: Does it Help Thwart HIV?
Author(s): Lajoie J, Boily-Larouche G, Juno JA, Kirwan SE and Fowke KRLajoie J, Boily-Larouche G, Juno JA, Kirwan SE and Fowke KR
The impact of HIV on the mucosal compartment is now well recognized and contributes to driving immune activation, a characteristic of HIV pathogenesis. The mucosal immune system is greatly affected by HIV from the first days of the infection. A massive depletion of the mucosal CD4+ T cells, over production of chemokines and cytokines and dysregulation of the epithelial barrier are some of the mucosal hallmarks of HIV infection. Individuals who control HIV replication, such as elite controllers (EC), or who maintain normal CD4+ T cell counts, such as long-term nonprogessors (LTNP), seem to maintain a balance within their mucosal environment that contributes to the delayed progression. At the female genital tract, which is the main route of entry of the virus in male to female heterosexual transmission, sexual activities have been associated with changes in mucosal immune activation tha.. View More»