Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Krunal Pardiwala
Tanzania
Review Article
The Potential of Intralesional Rose Bengal to Stimulate T-Cell Mediated Anti-Tumor Responses
Author(s): Ajay V Maker, Bellur Prabhakar and Krunal PardiwalaAjay V Maker, Bellur Prabhakar and Krunal Pardiwala
Rose Bengal (RB) is a red synthetic dye that was initially used in the garment industry and has been used safely for decades as a corneal stain by ophthalmologists. Antineoplastic properties of RB have also been observed, though the mechanism of action remained to be elucidated. Recently, interest in RB as a therapeutic cancer treatment has increased due to significant anti-tumor responses with direct tumor injection in human clinical trials for metastatic melanoma. In these patients, there has been the implication that RB may mount a T-cell mediated antitumor response and impart antigen-specific responses in distant bystander lesions. This article serves to evaluate the potential of intralesional rose bengal to stimulate T-cell mediated anti-tumor responses in in-vitro, pre-clinical, and clinical studies... View More»
DOI:
10.4172/2155-9899.1000343