Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Kohji Shirai
Department of Vascular Function, Sakura Hospital, School of Medicine,
564-1 Shimoshizu, Sakurashi, Chiba 285-8741
Japan
Review Article
Evaluation of Arteriosclerotic Vascular Disease with a New Noble Stiffness Indicator, Cardio-Ankle Vascular Index (CAVI)
Author(s): Kohji Shirai, Junji Utino, Atsuhito Saiki, Ichiro Tatsuno, Kazuhiro Shimizu and Mao TakahashiKohji Shirai, Junji Utino, Atsuhito Saiki, Ichiro Tatsuno, Kazuhiro Shimizu and Mao Takahashi
Arterial stiffness is a well-known predictor of arteriosclerotic vascular disease. One index of arterial stiffness was the pulse wave velocity (PWV). But, it is known that PWV depends on the blood pressure at measuring time. Cardio-ankle vascular index (CAVI) is derived from stiffness parameter beta, and reflects the stiffness of the artery from the origin of the aorta to the ankle as a whole. Conspicuous feature is independency from the blood pressure at measuring time. An administration of alfa-1 blocker, doxazosin decreased CAVI transiently. Prostacyclin analogue, beraprost also decreased CAVI. These results suggest that CAVI might reflect the smooth muscle cell contracture. CAVI showed high value with aging, and in patients with cerebral infarction, coronary stenosis, and chronic hemodialysis, suggesting that CAVI is reflecting systemic vascular arteriosclerosis. As for the risks .. View More»
DOI:
10.4172/2155-9880.S1-004