Journal of Thyroid Disorders & Therapy
Open Access
ISSN: 2167-7948
+44 1300 500008
ISSN: 2167-7948
+44 1300 500008
Kiyohiro Hamatani
Radiation Effects Research Foundation,
5-2 Hijiyama Park, Minamiku, Hiroshima-shi, Hiroshima 732-0815
Japan
Review Article
Thyroid Cancer: Molecular Characteristics of Radiation-Associated Papillary Thyroid Cancer, with a Special Reference to of Atomic Radiation Exposure
Author(s): Kiyohiro Hamatani
Kiyohiro Hamatani
Among atomic-bomb (A-bomb) survivors of Hiroshima and , incidence of thyroid cancer significantly increased after exposure to nuclear radiation. This review will focus on the initiating gene alterations in the development of adult-onset papillary thyroid cancer (PTC) among A-bomb survivors. The effects of A-bomb radiation on chromosomal rearrangements (RET and NTRK1 rearrangements) and point mutations (BRAF and RAS mutations) after exposure were different. In contrast to PTC cases with point mutations, PTC cases with chromosomal rearrangements were observed more frequently among those exposed to high radiation doses compared to low doses, and these cases developed cancer earlier after exposure than did cases with point mutations. Interestingly, PTC cases with non-detected gene alterations were found more frequently among patients who were exposed to high radiation doses and who develo.. View More»
DOI:
10.4172/2167-7948.1000183