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Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Kim O’Neill

Kim O’Neill

Provo, Utah
Tanzania

Publications
  • Review Article
    Macrophage Polarization and Its Role in Cancer
    Author(s): Evita Weagel, Curren Smith, Ping Guo Liu, Richard Robison and Kim O’NeillEvita Weagel, Curren Smith, Ping Guo Liu, Richard Robison and Kim O’Neill

    The immune system plays an important role in the development of, and progression of cancer. Macrophages exhibit a variety of responses according to varying stimuli, and express different functions depending upon the microenvironment surrounding them. Macrophages can be pro-inflammatory (M1) or anti-inflammatory (M2). Research studies have shown that infiltration of macrophages can account for >50% of the tumor mass in some cancers, aid in metastasis by inducing angiogenesis, and signify a poor prognosis. Macrophages that migrate to the tumor site, remain there, and aid in angiogenesis and metastasis are termed tumor associated macrophages (TAMs) and are thought to express an M2 phenotype. This review will examine the polarization states of macrophages, their functions and role in cancer, their activation pathways and metabolism, and potential approaches.. Read More»
    DOI: 10.4172/2155-9899.1000338

    Abstract PDF

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