Journal of Clinical and Cellular Immunology
Open Access

Kezhong Zhang

Publications

• Research Article
  ER Stress-induced Inflammasome Activation Contributes to Hepatic Inflammation and Steatosis
  Author(s): Jinyu Zhang, Kezhong Zhang, Zihai Li and Beichu Guo Jinyu Zhang, Kezhong Zhang, Zihai Li and Beichu Guo
  
  Endoplasmic reticulum (ER) stress functions as a protein folding and quality control mechanism to maintain cell homeostasis. Emerging evidence indicates that ER stress is also involved in metabolic and inflammatory diseases. However, the link between ER stress and inflammation remains not well characterized. In this study, we have demonstrated that ER stress-induced inflammasome activation plays a critical role in the pathogenesis of hepatic steatosis. By utilizing genetic and pharmacological agent-induced hepatic steatosis animal models, we found that hepatic steatosis was associated with inflammasome activation and ER stress. Our results show that caspase-1 ablation alleviated liver inflammation and injury. Liver tissues from caspase-1 KO mice had significantly reduced production of IL-1β under ER stress conditions. We also found that ER stress promoted inflammasome activation .. View More»
  DOI: 10.4172/2155-9899.1000457

  Abstract PDF

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