Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Kaomei Guan
University Medical Center Göttingen,
Robert-Koch-Str. 40, 37075 Gottingen
Germany
Review Article
Cardiac Progenitor Cells and their Therapeutic Application for Cardiac Repair
Author(s): Lukas Cyganek, Simin Chen, Thomas Borchert and Kaomei GuanLukas Cyganek, Simin Chen, Thomas Borchert and Kaomei Guan
Heart disease is the principal cause of death in humans. Stem cell-based therapy for heart regeneration has long been seen as a potential application since the heart lacks adequate intrinsic regenerative potential. In the cardiovascular field, clinical trials have already been carried out by implantation of both bone marrow-derived stem cells and cardiac resident progenitor cells derived from the adult heart tissue into the injured myocardium to restore the functionality of the heart after damage. However, before a robust stem and progenitor cell-based therapy for cardiovascular diseases can be applied in the clinical setting, more research is necessary to generate sufficient quantities of functional cardiomyocytes from stem cells and to understand behavior of cardiomyocytes upon transplantation. A comprehensive understanding of the developmental processes involved in cardiogenesis mi.. View More»
DOI:
10.4172/2155-9880.S11-008