Journal of Thyroid Disorders & Therapy
Open Access
ISSN: 2167-7948
+44 1300 500008
ISSN: 2167-7948
+44 1300 500008
June-Key Chung
Seoul National University Hospital Seoul National University College of Medicine,
Seoul
Taiwan
Case Report
Multiglandular Autoimmune Diseases of the Thyroid, Salivary Gland, and Liver along with Atrophic Gastritis: A Case Report
Author(s): Soo Jin Lee, June-Key Chung, Taemoon Chung, Hyewon Youn, Jin Chul Paeng, Gi Jeong Cheon, Keon Wook Kang and Dong Soo LeeSoo Jin Lee, June-Key Chung, Taemoon Chung, Hyewon Youn, Jin Chul Paeng, Gi Jeong Cheon, Keon Wook Kang and Dong Soo Lee
Multiple mechanisms have been suggested for the pathogenesis of these multiglandular autoimmune diseases. One of proposed mechanisms in the multiglandular autoimmune disease is initiated by antibodies. However, the results are not definitive and remain controversial. We investigated a woman with multiple autoimmune diseases, in whose serum the mRNA of sodium iodide symporter (NIS) was found by nested reverse transcription polymerase chain reaction (RT-PCR). In this patient, multiple autoimmune diseases were initially developed as thyroiditis, followed by Sjögren syndrome, hepatitis, and finally a diagnosis of atrophic gastritis. NIS is known to be expressed on organs affected by these diseases. The mRNA of NIS was found in the serum of this patient by nested RT-PCR. The pathogenesis of multiglandular autoimmune disease is still not clear. We suggest that anti NIS antibodies can s.. View More»
DOI:
10.4172/2167-7948.1000164