Clinical & Experimental Cardiology
Open Access

Jun Yao Liu

Publications

• Research Article
  Pressure Overload Promotes HMGB1 Signaling in the Ischemic-reperfused Heart
  Author(s): Babak Baban, Jun Yao Liu and Mahmood S MozaffariBabak Baban, Jun Yao Liu and Mahmood S Mozaffari
  
  Damage-Associated Molecular Patterns (DAMPs) are released following tissue injury and can activate proinflammatory pathways. Prototypical DAMPs include the High-Mobility Group Box 1 (HMGB1) protein which is released from necrotic cells. In turn, HMGB1 promotes inflammation via mechanisms likely involving phosphorylation/ activation of c-Jun-NH2-Terminal Kinase (JNK) and production of the inflammasome-associated cytokine, interleukin- 1β (IL-1β). We have shown that pressure overload increases infarct size in association with poorer functional recovery of the heart subjected to an ischemia-reperfusion insult. This study tested the hypothesis that pressure overload augments HMGB1 expression in association with increased IL-1β generation and JNK phosphorylation thereby contributing to increased tissue injury. Accordingly, hearts of male Sprague-Dawley rats were subjected to.. View More»
  DOI: 10.4172/2155-9880.1000286

  Abstract PDF

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