Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Julio Cesar Francisco
Instituto de Pesquisa Pelé Pequeno Príncipe,
Av. Silva Jardim, 1632, Curitiba–PR, Brasil CEP 80250-060
Brazil
Research Article
The Effects of Total Thyroidectomy on Cardiac Function in Old Rats using Echocardiographic Measures
Author(s): Julio Cesar Francisco, Ricardo Correa Cunha, Marco André Cardoso, Rossana Baggio Simeoni, Luiz Cesar Guarita-Souza, Nelson Itiro Miyague and Katherine Athayde Teixeira de CarvalhoJulio Cesar Francisco, Ricardo Correa Cunha, Marco André Cardoso, Rossana Baggio Simeoni, Luiz Cesar Guarita-Souza, Nelson Itiro Miyague and Katherine Athayde Teixeira de Carvalho
Objectives: Doppler Echocardiography has been shown to reflect thyroid hormone action in primary thyroid dysfunction. The aim of the present study was to evaluate the cardiac function after total thyroidectomy in old rats using echocardiographic measures.
Methods: Female Wistar rats aged 24 months old (referred to as adult) were divided into 2 groups with 15 animals each: Euthyroid (Eut) and Hypothyroid (Hypo) rats. Hypothyroidism was induced by total thyroidectomy. The plasmatic levels of T3, T4, TSH and free ionic calcium were measured. Echocardiographic analysis was performed using the following parameters: left ventricular end-diastolic (LVED) left ventricular end-systolic (LVES), ejection fraction (EF) and Tei index.
Results: In both groups, the LVES ranged from 0.2 to 0.5 p <0.048 and the.. View More»
DOI:
10.4172/2155-9880.S11-006