Journal of Thyroid Disorders & Therapy
Open Access
ISSN: 2167-7948
+44 1300 500008
ISSN: 2167-7948
+44 1300 500008
Joseph M Curry
Philadelphia
Tanzania
Review Article
Thyroid Cancer Metabolism: A Review
Author(s): Kurren S Gill, Patrick Tassone, James Hamilton, Nikolaus Hjelm, Adam Luginbuhl, David Cognetti, Madalina Tuluc, Ubaldo Martinez-Outschoorn, Jennifer M Johnson and Joseph M CurryKurren S Gill, Patrick Tassone, James Hamilton, Nikolaus Hjelm, Adam Luginbuhl, David Cognetti, Madalina Tuluc, Ubaldo Martinez-Outschoorn, Jennifer M Johnson and Joseph M Curry
Metabolic dysregulation within the tumor microenvironment (TME) is critical to the process of tumorigenesis in various cancer types. Thyrocyte metabolism in papillary and anaplastic thyroid cancer, however, remains poorly characterized, and studies analyzing the role of multicompartment metabolism in thyrocyte oncogenesis are sparse. We present a review of the current knowledge on cellular metabolism in non-cancerous and cancerous thyroid tissues, focusing on the monocarboxylate transporters MCT1 and MCT4, and on a transporter of the outer mitochondrial membrane TOMM20. Understanding the metabolic phenotype of tumor cells and associated stromal cells in thyroid cancer can have profound implications on the use of biomarker staining in detecting subclinical cancer, imaging as it relates to expression of various transport proteins, and therapeutic interventions that manipulate this dysre.. View More»
DOI:
10.4172/2167-7948.1000200