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Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Jonathan A. Lindquist

Publications
  • Review Article
    T cell Metabolism - Regulating Energy
    Author(s): Clemens Cammann, Burkhart Schraven and Jonathan A. LindquistClemens Cammann, Burkhart Schraven and Jonathan A. Lindquist

    Antigenic stimulation of T cells initiates a change from the resting state into an activated one mediated by triggering the T cell receptor (TCR). This change is characterized by rapid proliferation, differentiation and acquisition of effector functions. To maintain the energetic needs accompanied by this processes, T cells are able to adapt their uptake and utilization of extracellular nutrients. Proliferation and differentiation into distinct subsets of T lymphocytes like effector-, regulatory-, and memory T cells is mediated by antigens, various cytokines and growth factors through their respective signaling pathways they trigger. Since these subsets acquire different functions in the immune system, their metabolic profiles also differ. Throughout the last decade the role metabolism was intensively investigated and evolved into one major part in understanding activation and differe.. View More»
    DOI: 10.4172/2155-9899.S12-012

    Abstract PDF

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