Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Johanne M Kaplan

Johanne M Kaplan

Tanzania

Publications
  • Review Article
    Insights into the Mechanisms of the Therapeutic Efficacy of Alemtuzumab in Multiple Sclerosis
    Author(s): Mark S Freedman, Johanne M Kaplan and Silva Markovic-Plese Mark S Freedman, Johanne M Kaplan and Silva Markovic-Plese

    The pathogenesis of multiple sclerosis (MS) is thought to involve peripheral activation of immune cells against central nervous system (CNS) antigens and their migration across the blood–brain barrier, leading to CNS inflammation and neurodegeneration. Alemtuzumab, a humanized anti-CD52 monoclonal antibody that rapidly depletes CD52- expressing cells from the circulation, is being investigated as a new treatment option in relapsing-remitting MS (RRMS). Clinical and radiologic results indicate robust suppression of inflammation related to the depletion of T and B lymphocytes during each treatment course of alemtuzumab. Furthermore, several lines of evidence suggest that the long-term clinical effects of alemtuzumab are attributable to qualitative changes in repopulating lymphocyte subsets potentially leading to a rebalancing of the immune system. Here, we review the contribution .. View More»
    DOI: 10.4172/2155-9899.1000152

    Abstract PDF

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