Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Joan M. Cook-Mills

Joan M. Cook-Mills

McGaw-M304, 240 E. Huron, Chicago, IL 60611

  • Review Article
    Isoforms of Vitamin E Differentially Regulate PKCα and Inflammation: A Review
    Author(s): Joan M. Cook-MillsJoan M. Cook-Mills

    Vitamin E regulation of disease has been extensively studied but most studies focus on the α-tocopherol isoform of vitamin E. These reports indicate contradictory outcomes for anti-inflammatory functions of the α-tocopherol isoform of vitamin E with regards to animal and clinical studies. These seemingly disparate results are consistent with our recent studies demonstrating that purified natural forms of vitamin E have opposing regulatory functions during inflammation. In this review, we discuss that α-tocopherol inhibits whereas γ-tocopherol elevates allergic inflammation, airway hyperresponsiveness, leukocyte transendothelial migration, and endothelial cell adhesion molecule signaling through protein kinase Cα. Moreover, we have demonstrated that α-tocopherol is an antagonist and γ-tocopherol is an agonist of PKCα through direct bindin.. View More»
    DOI: 10.4172/2155-9899.1000137

    Abstract PDF

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