Andrology-Open Access

Andrology-Open Access
Open Access

ISSN: 2167-0250

Jie Zhao

Jie Zhao


  • Research Article
    Epidermal Growth Factor Signaling Regulates the Expression of Metastasis Tumor Antigen 1 in Mouse Pachytene Spermatocyte
    Author(s): Tian Yang, Jie Zhao and Wei LiTian Yang, Jie Zhao and Wei Li

    Selective regulation of gene transcription is clearly important for cells to orchestrate an adaptive response to heat stress. We previously showed that Metastasis Associated Protein 1 (MTA1), a component of the nucleosome remodeling and deacetylase (NuRD) complex, operates as a negative coregulator of p53 in the maintenance of the apoptotic balance in pachytene spermatocytes (PS) after heat stress, although specific mechanisms are not well defined. The purpose of the current study was to investigate potential upstream signaling events activating MTA1 pathway in murine PS. Using murine sialoadenectomy model, it was demonstrated that deprivation of circulated EGF significantly impaired the in vivo expression of MTA1 in the PS. The upstream regulation of MTA1 expression during meiosis by endogenous EGF was further confirmed in vitro using a selective Epidermal Growth Factor Receptor (EGF.. View More»
    DOI: 10.4172/2167-0250.1000110

    Abstract PDF

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