Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
+44 1223 790975
ISSN: 2736-6588
+44 1223 790975
Jianzhou Meng
Chinese Academy of Medical Sciences and Peking Union Medical College,
Beijing, 100050
China
Research Article
Pilot Study of a Novel Anti-Tubercular Acylhydrazone Schiff Base Derivative
Author(s): Jianzhou Meng, Qing He, Xiao Wang, Yan Guan, Yishuang Liu and Chunling XiaoJianzhou Meng, Qing He, Xiao Wang, Yan Guan, Yishuang Liu and Chunling Xiao
Aim: This study aimed to discover new Anti-Mycobacterium Tuberculosis (MTB) chemicals for treating drugresistant MTB.
Method: A phenotypic screening model was construed using MTB H37Rv (ATCC27294) for searching antituberculosis chemicals. Minimal inhibitory concentrations (MICs) of the positive compounds to sensitive and resistant MTB strains were detected to confirm antibacterial activities. The pharmacokinetic and metabolic properties and intracor-poral anti-MTB activity of the promising compound were determined in mice to assess drug suitability.
Results: HMPP, an acyl hydrazone Schiff base derivative of these compounds, was obtained based on this model. HMPP potently inhibited H37Rv (MIC, 0.72 μM) and a multiple drug-resistant MTB strain (MIC, 45 μM). The half maximal inhibitory concentrations (IC50) for Vero a.. View More»