Journal of Clinical and Cellular Immunology
Open Access

Jezrom B. Fordham

Publications

• Research Article
  miR-24 Regulates Macrophage Polarization and Plasticity
  Author(s): Jezrom B. Fordham, Afsar R. Naqvi and Salvador NaresJezrom B. Fordham, Afsar R. Naqvi and Salvador Nares
  
  Objective: MicroRNAs (miRNA) are ubiquitous regulators of human biology and immunity. Previously, we have demonstrated an inhibitory role for miR-24 in the phagocytosis of Escherichia coli and Staphylococcus aureus bioparticles and the induction of cytokine secretion in response to lipopolysaccharide (LPS) of the same origin; also, we have identified divergent and convergent miRNA responses to LPS from the periodontopathic pathogens Aggregatibacter actinomycetemcomitams (Aa) and Porphyromonas gingivalis (Pg), and revealed cigarette smoke extract as an environmental modifier of Pg LPS structure (Pg CSE) impacting macrophage miRNA responses. This study was designed to investigate the role of miR-24 on macrophage polarization and plasticity. Methods: Primary human macrophages were differentiated from CD14+ monocytes isolated fro.. View More»
  DOI: 10.4172/2155-9899.1000362

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