Journal of Thyroid Disorders & Therapy
Open Access
ISSN: 2167-7948
+44 1300 500008
ISSN: 2167-7948
+44 1300 500008
Jeremy M G Taylor
United States
Research Article
Retrospective Study of Sirolimus and Cyclophosphamide in Patients with Advanced Differentiated Thyroid Cancers
Author(s): Poorni M Manohar, Lauren J Beesley, Jeremy M G Taylor, Elizabeth Hesseltine, Megan R Haymart, Nazanene H Esfandiari, David A Hanauer and Francis P WordenPoorni M Manohar, Lauren J Beesley, Jeremy M G Taylor, Elizabeth Hesseltine, Megan R Haymart, Nazanene H Esfandiari, David A Hanauer and Francis P Worden
Background: We hypothesize that the combination of an mTOR inhibitor, sirolimus, with a well-known cytotoxic agent, cyclophosphamide, provides a well-tolerated and promising alternative treatment for advanced, differentiated thyroid cancers (DTC).
Methods: This retrospective review extracted data from patients treated for advanced DTC at the University of Michigan Comprehensive Cancer Center from 1995 through 2013. Fifteen patients treated with combination sirolimus and cyclophosphamide were identified as the sirolimus+cyp group. Seventeen patients treated with standard of care and enrolled in clinical trials were identified as the comparison group.
Results: The one-year progression free survival rate (PFS) was 0.45, 95% CI [0.26, 0.80] in the sirolimus+cyp population and 0.30, 95% CI [0.13, 0.67] in the comparison.. View More»
DOI:
10.4172/2167-7948.1000188