Immunome Research

Immunome Research
Open Access

ISSN: 1745-7580


Jasna Ajdukovic

Jasna Ajdukovic
Independent researcher, Sinj,

  • Short Communication
    Colorectal Cancer and NLRP-Current Knowledge
    Author(s): Jasna AjdukovicJasna Ajdukovic

    Inflammasomes activated by different stimuli in colorectal cancer show dual effect on cancer’s destiny. Activation of caspase-1 results in maturation of IL-1β and IL-18. IL-1β suppresses NK and T cells activity against tumor, induces expression of metastatic genes and stimulates the production of proinflammatory leukines, but it also enhances NK cell–mediated death of colon carcinoma cells. IL-18 promoter polymorphisms in humans increase risk for colorectal cancers. One variant of NLRP3 gene in human is connected with increased susceptibility to colorectal cancer. Expression levels of NLRP1, NLRP3, NLRC4 were significantly reduced in human CRC compared with healthy controls. Nlrp3 −/−mice exhibited increased colorectal cancer and metastasis in liver. NLRP3 have an important role in the Epithelial-Mesenchymal Transition (EMT) of colorec.. View More»
    DOI: 10.4172/1745-7580.1000153

    Abstract PDF

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