Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Janet K. Yamamoto
College of Veterinary Medicine,
P.O. Box 110880, Gainesville, FL 32611-0880
Tanzania
Review Article
Conserved HIV Epitopes for an Effective HIV Vaccine
Author(s): Bikash Sahay, Cuong Q. Nguyen and Janet K. YamamotoBikash Sahay, Cuong Q. Nguyen and Janet K. Yamamoto
Despite major advances in antiretroviral therapy against HIV-1, an effective HIV vaccine is urgently required to reduce the number of new cases of HIV infections in the world. Vaccines are the ultimate tool in the medical arsenal to control and prevent the spread of infectious diseases such as HIV/AIDS. Several failed phase-IIb to –III clinical vaccine trials against HIV-1 in the past generated a plethora of information that could be used for better designing of an effective HIV vaccine in the future. Most of the tested vaccine candidates produced strong humoral responses against the HIV proteins; however, failed to protect due to: 1) the low levels and the narrow breadth of the HIV-1 neutralizing antibodies and the HIV-specific antibody-dependent Fc-mediated effector activities, 2) the low levels and the poor quality of the anti-HIV T-cell responses, and 3) the excessive respon.. View More»
DOI:
10.4172/2155-9899.1000518