Immunome Research

Immunome Research
Open Access

ISSN: 1745-7580

J Jason Collier

J Jason Collier
Laboratory of Islet Biology and Inflammation, Pennington Biomedical Research Center,
6400 Perkins Rd., Baton Rouge, LA 70808

  • Editorial
    Insulitis and Diabetes: A Perspective on Islet Inflammation
    Author(s): Susan J Burke and J Jason CollierSusan J Burke and J Jason Collier

    Immune cell infiltration into pancreatic islets (termed insulitis) has been linked with destruction of pancreatic β-cells and thus with onset of diabetes mellitus. Recently published guidelines for reporting insulitis may generate some deliberation on pancreatic islet inflammation and a re-examination of the role that immune cells play in the process of β-cell death and dysfunction. Herein, we offer the viewpoint that a mild insulitis (e.g., 2-fold increase in leukocytic infiltration) would be sufficient to produce an adequate supply of inflammatory molecules capable of initiating and maintaining an inflammatory state within the pancreatic islets... View More»
    DOI: 10.4172/1745-7580.S2.e002

    Abstract PDF

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