Journal of Clinical and Cellular Immunology
Open Access

Ian P. Lewkowich

Publications

• Research Article
  IL-17A in Asthma - A Question of Severity
  Author(s): Ian P. LewkowichIan P. Lewkowich
  
  Allergic asthma is a chronic inflammatory disease of the lung driven by aberrant responses to normally innocuous environmental allergens. Disease is characterized by excessive IgE synthesis, eosinophilic pulmonary inflammation, mucus hypersecretion, and airway remodeling, and airway hyperresponsiveness - all leading to the clinical features of disease - reversible episodes of coughing, shortness of breath and wheezing. While the excessive production of cytokines like IL-4, IL-5 and IL-13 by allergen specific-Th2 cells is sufficient to explain most features of allergic asthma, increasing evidence suggests that the Th2 paradigm does not explain the full spectrum of disease severity. In particular, severe asthmatics represent a small subset of asthmatics, in which disease is associated with more severe airway reactivity, a mixed eosinophilic/neutrophilic infiltrate, and insensitivity to .. View More»
  DOI: 10.4172/2155-9899.1000107

  Abstract PDF

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