Journal of Clinical and Cellular Immunology
Open Access

Hiroyuki Nakayama

Publications

• Commentary
  Bitter Components in Beer Regulate Microglial Inflammation and Prevent Cognitive Decline
  Author(s): Yasuhisa Ano, Akihiko Takashima and Hiroyuki Nakayama Yasuhisa Ano, Akihiko Takashima and Hiroyuki Nakayama
  
  Epidemiological studies suggest that moderate consumption of alcoholic beverages can reduce the risk of dementia . Recent work has demonstrated that intake of iso-α-acids, the bitter components in beer; prevent Alzheimer’s disease pathology by regulating microglial function. In a transgenic mouse model of Alzheimer’s disease, iso-α-acid intake led to a significant reduction of Aβ and inflammatory cytokines. In addition, iso-α-acids enhanced microglial phagocytosis of Aβ and induced microglia to an anti-inflammatory M2 type. These findings suggest that iso-α-acid consumption in daily life may be beneficial in preventing dementia. .. View More»
  DOI: 10.4172/2155-9899.1000509

  Abstract PDF

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