Immunome Research
Open Access
ISSN: 1745-7580
ISSN: 1745-7580
Higazi AM
Egypt
Research Article
Comparison of the Immunity Status in-Between Children with β-Thalassaemia
Major Receiving Different Treatment Modalities: A Single Egyptian District
Study
Author(s): Mahmoud SS, Mohamed GB, Hakeem GLA, Higazi AM, Nafady AAH, Farag NM, Mahrous DM, Kamal NN, Hassan Z, Aziz EA and Shaban AMahmoud SS, Mohamed GB, Hakeem GLA, Higazi AM, Nafady AAH, Farag NM, Mahrous DM, Kamal NN, Hassan Z, Aziz EA and Shaban A
Background: β-thalassaemia major is one of the chronic hemolytic anemias resulting from defect in β-globin chain. It requires frequent blood transfusion plus other treatment modalities. These treatment modalities may be associated with certain immunologic modulations.
Objective: To assess the immunity status in children with β-thalassaemia major under different treatment regimens within El Minia, Egypt.
Subjects and Methods: One hundred forty-four children were enrolled and classified into four groups. Thirty-six β-thalassaemia patients treated only with blood transfusion (group I). Thirty-six patients treated with transfusion and iron chelation (group II). Thirty-six patients treated with transfusion, iron chelation and subjected to splenectomy (group III). Group IV involved thirty-six apparent.. View More»
DOI:
10.4172/1745-7580.10000127