Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Hideki Ohyama
Hyogo College of Medicine,
1-1 Mukogawa-cho, Nishinomiya 663-8501
Japan
Review Article
T-cell Responses Involved in the Predisposition to Periodontal Disease: Lessons from Immunogenetic Studies of Leprosy
Author(s): Hideki Ohyama, Nahoko Kato-Kogoe, Kazu Takeuchi-Hatanaka, Koji Yamanegi, Naoko Yamada, Keiji Nakasho, Sho Matsushita and Nobuyuki TeradaHideki Ohyama, Nahoko Kato-Kogoe, Kazu Takeuchi-Hatanaka, Koji Yamanegi, Naoko Yamada, Keiji Nakasho, Sho Matsushita and Nobuyuki Terada
Periodontitis, which involves loss of periodontal attachment and resorption of alveolar bone, is initially caused by infection with many kinds of anaerobic, gram-negative bacteria forming a subgingival biofilm. To prevent bacterial invasion, host defense mechanisms need to recruit many kinds of immunoregulatory cells, including helper T (Th) cells which play a central immune-regulatory role against periodontal infection. Similar to many infectious diseases, susceptibility to periodontal disease is partially determined by individual differences in Th cell responsiveness, especially cytokine production, against periodontopathic pathogens. Susceptibility to periodontitis has been associated with gene polymorphisms of several cytokines such as interleukin (IL)-2, IL-4, IL-6 and IL-10, but these correlations are predominantly weak due to their multifactorial nature. Distinct from these stu.. View More»
DOI:
10.4172/2155-9899.S1-005